Wythe County, Virginia, is located in Southwest Virginia, at the crossroads of I-81 and I-77. Wythe County lies within a one day drive of much of the nation’s population.
| City | Miles | Kilometers |
| Atlanta, GA | 350 | 563 |
| Baltimore, MD | 350 | 563 |
| Birmingham, AL | 473 | 761 |
| Boston, MA | 744 | 1197 |
| Charlotte, NC | 140 | 225 |
| Chicago, IL | 588 | 946 |
| Cincinnati, OH | 370 | 595 |
| Cleveland, OH | 375 | 604 |
| Columbia, SC | 264 | 425 |
| Columbus, OH | 368 | 592 |
| Detroit, MI | 487 | 784 |
| Jacksonville, FL | 540 | 869 |
| Memphis, TN | 562 | 904 |
| Nashville, TN | 276 | 444 |
| New York City | 544 | 875 |
| Norfolk, VA | 319 | 513 |
| Philadelphia, PA | 442 | 711 |
| Pittsburgh, PA | 345 | 555 |
| Raleigh-Durham, NC | 160 | 257 |
| Richmond, NC | 255 | 410 |
| St. Louis, MO | 540 | 869 |
| Washington, DC | 301 | 484 |